Pharmaceutical Science Project Topics with available Materials

1) Improving Stroke Prevention And Quantifying Outcomes Using A United States' City Model: Intervention Measurement Through Population Survey And Hospital-based Study

PROPOSAL: ABSTRACT Background: Currently stroke represents a serious problem in public health as one of the leading causes of  mortality and morbidity worldwide [1-3] with developing countries accounting for 85% of global deaths from stroke  [1, 3-5]. A very good example explains how stroke seems to be increasing in Nigeria and the case fatality... Continue Reading
  • Type:Project
  • ID:PHS0088
  • Pages:106

2) Assessment Of Heavy Metal Contents In Selected Herbal Medicines In Nigeria

The use of herbal medicines, despite the advancement in production of orthodox ones, has been on the increase, both in underdeveloped, developed and developing countries like Nigeria in particular. The approval of these herbal remedies by regulatory bodies like the National Agency for Food and Drug Administration Control, (NAFDAC) in Nigeria has... Continue Reading

3) Biosynthesis Of Silver Nanoparticles (agnps) Using Spondias Mombin Extract As A Bioreducing Agent

The field of nano science plays a crucial role in modern research and technology, offering unparalleled opportunities for innovation. Spondias mombin extract is used in this study as a bioreducing agent for the biosynthesis of silver nanoparticles (AgNPs). The properties of these nanoparticles are compared. As the color of the extract changed from... Continue Reading

4) Anti Inflammatory Activity Of The Fatty Seed Extract Of Vitellaria Paradoxa (sapotaceae)

  Fatty seed extracts of Vitellaria paradoxa (Sapotaceae), an indigenous plant of West Africa is a popular remedy for arthritis and swellings. This study investigated the knowledge, prevalence and pattern of use of the fatty extract also known as shea butter in clinically diagnosed arthritic patients as well as its effects on acute... Continue Reading

5) Synthesis And Anti-inflammatory Properties Of Aminomethyl Derivatives Of 2 Naphthol

The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid diseases cannot be over-emphasized. As this disease is characterized by chronic inflammation, it is usual to test compounds for anti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic... Continue Reading
  • Type:Project
  • ID:PHS0084
  • Pages:197

6) Novel Drug Delivery Systems Containing Artesunate And Amodiaquine

Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered... Continue Reading
  • Type:Project
  • ID:PHS0083
  • Pages:195

7) Diversity And Antibiogram Of Microbial Contaminants Isolated From Foods Hawked In Nsukka Metropolis : Consideration For Public Health

Hawked foods are cheap and easily accessible and have met the food needs of people in many cities and towns of developing countries. This study was aimed at ascertaining the diversity of microbial contaminants in foods hawked in Nsukka town. Seven different food samples of cooked foods hawked in Nsukka were examined for the presence of... Continue Reading
  • Type:Project
  • ID:PHS0082
  • Pages:100

8) Anti Microbial And Phytochemical Studies On Selected Nigerian Medicinal Plants: (1) Anti Microbial And Phytochemical Properties Of Phyllanthus Discoideus (euphorbiaceae).

The aqueous methanolic extracts of 20 selected plant parts were screened for in-vitro antimicrobial activity against clinical strains of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia, Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans at a test concentration of 10mg/ml using... Continue Reading

9) Physico-technical And Tableting Properties Of Grades Of Microcrystalline Cellulose Derived From Sorghum And Andropogon Plants

CONTENTS Page Acknowledgement ........................................................................................................... iv Abstract ................................................................................................................................. vi List of Tables... Continue Reading
  • Type:Project
  • ID:PHS0080
  • Pages:264

10) Evaluation Of The Antinociceptive And Anxiolytic-like Activities Of Leaf Extract And Fraction Of Phyllanthus Muellerianus Kuntze

The anxiolytic and antinociceptive properties of the leaf extract and fraction of Phyllanthus muellerianus Kuntze (Phyllanthaceae) were investigated.The extract (MME; 500.18 g; 10%w/w), obtained by cold maceration in 1:1 mixture of methylene chloride: methanol for 48 h, was fractionationed in a silica gel column which yielded the ethyl... Continue Reading
  • Type:Project
  • ID:PHS0079
  • Pages:152

11) Effect Of Ethanolic Leaf Extract Of Dialium Guineense Wild. (fabaceae) On Oral Glucose Tolerance In Mice And Alloxan-induced Diabetic Female Rats

This research project studied the effect of ethanolic leaf extract of Dialium guineense Willd (Fabaceae) on oral glucose tolerance in mice and alloxan-induced diabetic female rats.  The ethanolic leaf extract was prepared by marcerating 500g of the dried, milled leaves of D. guineense in 3L of 96% ethanol in a suitable sized plastic bucket/bowl... Continue Reading
  • Type:Project
  • ID:PHS0078
  • Pages:105

12) Investigation Of Anti-hyperglyceamic Properties Of The Aqueous Extract Of Green Peel Of Musa Acuminata 'naj(jtembe Cultivar'

The objective of this research was to investigate the anti-hyperglyceamic properties of the aqueous extract green peel of (Banana) musa acuminata 'nakitembe cultivar' in alloxan induced diabetic rats. The extract used was obtaned from the green banana dried and phytochemical analysis and acute toxicity study carried out. Alloxan was... Continue Reading

13) Assessment Of Antibiotic Sensitivity Patterns Of Salmonella Typhimurium, Pseudomonas Aeru'ginosa, Klebsiella Pneumoniae Isolates From Barn Swallow Droppings In Ishaka Town, Bushenyi District,

  Introduction: It has been reported that the main factors behind the emergence of drug resistance is the use and misuse of antimicrobial drugs during the past few decades, but there is also the aspect of epidemic spread of drug-resistant bacteria as a factor. This has caused a major concern with serious implications in human and animal... Continue Reading

14) Assessment Of Rational Prescribing In General Outpatient Department Of Kampala International University Teaching Hospital, Western Uganda

  Prevention of irrational use of medicines may reduce healthcare costs and potentially save I ives. In line with World Health Organization (WHO) recommendation, a retrospective, cross-sectional descriptive study was carried out to obtain information on prescribing in the general outpatient department of Kampala International University... Continue Reading

15) Profile Of Antibiotics Use At Regional Hospital Buea, South West Region Cameroon

The indiscriminate use of antibiotics has become a global problem with implications for effective therapy of infections and dose resistance. The objective of this study is to determine the profile of antibiotic use at the Regional Hospital Buea. The data used for this study was obtained using a Checklist and the data obtained were... Continue Reading

16) Analgesic And Anti-inflammatory Activities Of The Aqueous Leaf Extract Of Erlangea Tomentosa

Erlangea tomentosa is been used traditionally in the management of several diseases including pain and inflammation. However, their efficacy has not been scientifically validated. The aim of this study therefore is to investigate the analgesic and anti-inflammatory activities of the aqueous leaf extract. The plant materials were collected... Continue Reading

17) Efficacy Of Tiptop® Yogurt As A Source Of Probiotics Against Enteric Pathogens Isolated From Kiu-th Microbiology Laboratory

The study was conducted to evaluate the efficacy of tiptop yogurt as a some of probiotics against enteric pathogens isolated at KIU-TH. It was conducted to isolate and identify any probiotics available in yogurt, obtain cell free supernatants (bacteriocins) and expose them to 0 selected enteric pathogens, evaluate the effect of bacteriocins from... Continue Reading

18) The Effect Of Pharmacists' Monitoring Role On Clinical Outcomes Of Hypertensive Patients Attending Two Tertiary Referral Hospitals

TABLE OF CONTENTS DECLARATION .................................................................................................................................. i CERTIFICATION ............................................................................................................................... ii DEDICATION... Continue Reading

19) Assessment Of The Quality Of Fixed Dose Quinine Sulfate Tablets Sold In Bushenyi Based On The Bp Specifications

TABLE OF CONTENTS DECLARATION ........................................................................................................................................................ 1 APPROVAL... Continue Reading
  • Type:Project
  • ID:PHS0070
  • Pages:100

20) Assessment Of Effective Use Of Anti-epileptic Drug Therapy Among Patients At Kagando Hospital

TABLE OF CONTENTS DECLARATION ............................................................................................................................... i ACKNOWLEDGEMENT ................................................................................................................ ii DEDICATION... Continue Reading

21) A Pharmaceutical Equivalence Study Of The Selected Azithromycin 500 Mg Brands On The Ugandan Market

TABLE OF CONTENTS DECLARATION .......................................................................................................................................... ii DDEDICATION ............................................................................................................................................. iii ACKNOWLEDGEMENT... Continue Reading

22) Knowledge, Attitude And Practices Of Pharmacovigilance Among The Health Care Professionals At Ishaka Adventist Hospital

Table of Contents Declarations •...••.•...•....•...•.••••.•••••.•.•.•.•••.•.•..•.•..........•.•.....................................................................•.•.....•...•• i Approval... Continue Reading

23) Assessment Of Health Workers' Adherence To Standard Treatment Guidelines In Management Of Typhoid Fever At Kampala International University Teaching Hospital.

TABLE OF CONTENTS DECLARATION ............................................................................................................................. .i CERTIFICATION .......................................................................................................................... ii LIST OF ABREVIATIONS... Continue Reading

24) Evaluation Of Anti Poisoning And Protective Properties Of Elaeis O/eifera Kernel Extract In Orally Organophosphate Poisoned Albino Rats

Hepatotoxicity and oxidative stress are some of the molecular mechanism of Dichlorvos toxicity. This study aims at dertermining the antipoisoning and protective properties of Elaeis oleifera palm oil extract in orally dichlorvos poisoned albino rats. 35 rats were divided into seven groups each containig five rats served as subject for... Continue Reading

25) Extractive Value, Ash Value And Moisture Content Of Amaranths Dub/us Leaves ("dodo") In Bushenyi _ Ishaka Town Council, South Western Uganda

TABLE OF CONTENTS CONTENT PAGE Title ............................................................................................................................................ . Declaration .................................................................................................................................. i Dedication... Continue Reading

26) Evaluation Of Knowledge And Use Of Oral Contraceptives Among Women Aged Between 18 To 35 Years Attending Antenatal Clinic At Lira Regional Referral Hospital

TABLE OF CONTENTS DECLARATION ............................................................................................................................. i SUPERVISOR'S APPROVAL ....................................................................................................... ii DEDICATION... Continue Reading

27) Phytochemical Analysis And Antibacterial Activity Of Crassocephallum Vitelline Leaf Extracts

Table of Contents List of Figures ............................................................................................................................................ iii List of tables ............................................................................................................................................... iii... Continue Reading

28) Factors Affecting Prevalence Of Self Medication Of Antibiotics Among Adult Population In Ishaka-bushenyi Municipality

Introduction: The research deals with the factors affecting the prevalence of self-medication of antibiotics among adult population in Ishaka-Bushenyi Municipality. It was guided by the following objectives: to determine the prevalence of self-medication of antibiotics and other miscellaneous issues among the adult population in... Continue Reading

29) Assessment Of Knowledge, Attitudes And Practice Of Contraceptive Use Among Pregnant Women

TABLE OF CONTENT DECLARATION ..................................................................................................................................... i APPROVAL ........................................................................................................................................... ii LIST OF ABRREVIATIONS... Continue Reading

30) A Study To Assess The Feasibility Of Hda App; A Drug Information And Verification System Intended For Implementation In Uganda

TABLE OF CONTETS DECLARATION ......................................................................................................................... ! APPROVAL ............................................................................................................................... !! DEDICATION... Continue Reading

31) Phytochemical Screening, Quantification, And Fractionation Of Aqueous Methanolic Extract Of Spathodea Campanulata Stem Bark

Plants produce a good deal of secondary metabolites which have benefited mankind in various ways including treatment of diseases. The present study was carried out to identify and isolate the different phytochemicals present inS. campanulata stem bark aqueous methanolic extract, to quantify these phytochemicals, and to identify different... Continue Reading

32) Phytochemical Screening, Quantification And The Anti-inflammatory Activity Of The Methanolic Extract Of Ocimum Gratissimum Leaves

CHAPTER ONE 1.0 INTRODUCTION Medicinal plants have been of great important to the health of individual and communities. The medicinal value of these plants had some chemical active substances that produce a definite physiological action on the human body. Nature has served as a rich repository of medicinal plants for thousands of years and an... Continue Reading

33) Determination Of Antidotal And Protective Properties Of Elaeis Oleifem Frult Extract In Orally Organophosphate Poisoned Albino Rats

TABLE OF CONTENT DECLARATION ............................................................................................................................. i DEDI CA TI 0 N ................................................................................................................................ i i A C K N 0 W LEDG EM ENT... Continue Reading

34) Factors Affecting Utilization Of Focus Antenatal Care Services Among Pregnant Mothers Attending Antenatal Care In Kitagata Hospital-sheema District, Uganda.

Background: In Low and Medium income countries (LMICs) focus antenatal care (FANC) services are so low, below the recommended threshold. In Uganda, high maternal and neonatal mortalities have been attributed to the severe variations in F ANC coverage in rural communities. Aim: This study was to determine factors affecting utilization of... Continue Reading

35) Antibiotic Sensitivity Patterns Of Staphylococcus Aureus To Methillicin In Clinical Samples At Kid Teaching Hospital.

Back ground: Staphylococcus aureus is a gram positive bacteria that exists on the skin as nonnal flora. It is classified as Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA), where MRSA is resistant to beta-lactam antibiotics. MRSA has become a predominant pathogen in the health care... Continue Reading

36) Investigation Of Antibacterial Activity, Phytochemical Screening And The Extractive Value Of Different Solvents On Lawson/a Inermij(henna) Plant Leaf Extract.

The purpose of this study was to evaluate the antibacterial activity, to determine the most efficiency extractive solvents and phytochemical profile of Hot water, Methanol alcohol and Lemon juice extract of Lawsonia inermis (henna) leaf. The plant attracted the attention of researchers because of its use as anti-infective agent. The oily... Continue Reading

37) New Combination Methods Of Detecting Drug Interaction And Monitoring Adverse Drug Reactions In "close System Pharmacy"

Pharmacovigilance is an essential phenomenon in the rational use of medicine, providing information about ADR in general population. Tracking ADR in' close system pharmacy' which has relied on use of yellow forms and feed back following exposure to drugs has been inadequate. Alternative methods are therefore required. In the present... Continue Reading

38) Assessment Of The Chemical Composition And Pesticide Properties Of Cassia Didymobotrya Ash On Myzus Persicae Affecting Tomato Crops In Ishaka

Background: Myzus pe.rsicae (green peach aphids) are crop pests; they are among the most destructive insect pests on cultivated plants in temperate regions. Many of them are green in color, but others may be white wooly or black (McGravin,1993).Their damage to plants has made farming a complicated venture across the whole world. From the... Continue Reading

39) Comparative Pharmacopoeia Analysis Of Selected Brands Of Diclofenac Sodium Tablets Available In Western Uganda Pharmacies Based On Bp 2009

Jackground: Diclofenac is one of the most commonly used non-steroidal anti-inflammatory lrugs (NSAIDs) for the treatment of pain, rheumatism and other inflammatory conditions.Aim: ~his study aimed to investigate whether the selected brands of diclofenac sodium meet heir label specifications as well as the BP 2009.Materials and Methods:... Continue Reading

40) Pharmaco-economic Analysis Of Brands Of Antacid Formulations Available In Ishaka Town Using Titrimetric Method

Pharmaco-economics involves comparing the cost and consequences of products and services and Cost-effectiveness is the relationship between cost and effectiveness of a given drug. ANC of an antacid is one of the ways of evaluating effectiveness of antacid brands. ANC (mEq per unit dose) is the ability of the antacid to neutralize gastric... Continue Reading

41) Assessment Of Knowledge On Use Of Artemether Lumefantrine In Management Of Uncomplicated Malaria Among Outpatients At Klu-th

This study sought to assess the knowledge on the use of Artemether/ therapy in the management of uncomplicated malaria among out patients treated at KlU-TH. A cross sectional study design was employed in this study. Data was collected from August to October 2018 using a questionnaire by simple Random sampling and was entered and analyzed... Continue Reading

42) Development Of Lipid-based Microsuspensions For Ophthalmic Delivery Of Gentamicin

The bioavailability of drugs from conventional eye drops is generally low. Many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense... Continue Reading
  • Type:Project
  • ID:PHS0047
  • Pages:139

43) Effect Of Combined Treatment With Chloroquine And Artesunate On White Blood Cell Count Of Plasomdium Berghei Infected Albino Mice

Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and... Continue Reading

44) Effect Of Aqeuous Extract Of Rauwola Vomitoria Root Extract On Isolated Rabbit Intestine

Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with... Continue Reading

45) Anti-inflammatory And Analgesic Activities Of Alafia Barteri And It’s Possible Mechanisms Of Action.

ABSTACT The pharmacological effects of the metanolic root extract of the plant Alafia barteri Oliv. used commonly in West and Central Africa, from Guinea Bissau east to Cameroon and south to Congo, including Nigeria for the treatment of various diseases (including malaria, arthritis, eye infection an inflammation) was evaluated. The analgesic... Continue Reading

46) Anti-ulcerogenic Effects Of Chloroform Extract Of Chasmanthera Dependens On Indomethacin And Aspirin-iduced Ulcer In Rats

Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortality rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each for... Continue Reading

47) The Anxiolytic Activity Of Ethanolic Leaf Extract Of Culcasian Scadens In Experimental Animal Models

Objectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models . Methods:  The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided... Continue Reading

48) Neutralization Of The Lethal Effect Of Bitis Arietans Venomby Euphorbia Cotinifolia Leaf Extract

TABLE OF CONTENTS CONTENTS PAGE TITLE PAGE---------i DECLARATION--------ii CERTIFICATION--------iii DEDICATION--------iv ACKNOWLEDGEMENT-------v TABLE OF CONTENT-------vi LIST OF TABLES--------ix LIST OF FIGURES-------ix ABSTRACT---------x CHAPTER ONE INTRODUCTION AND LITERATURE REVIEW 1.1 TRADITIONAL MEDICINE-------1 1.2 MODERN MEDICINE--------4... Continue Reading

49) Evaluation Of The Antiplasmodial Activity Of Methanol Leaf Extract And Fractions Of Landolphai Owariesis P. Beauv (apocynaceae) In Mice

  Landolphia owariensis P. Beauv (Apocynaceae) is a woody liane commonly used in Africa for the treatment of gonorrhea, worm infestation and malaria. The methanol leaf extract (ME) of L. owariensis was obtained by cold maceration and then fractionated into nhexane (nHF), ethylacetate (EF) and methanol (MF) fractions. The methanol extract... Continue Reading

50) Evaluation Of Hypoglycaemic Effect And Phytochemical Constituents Of Methanol Extract Of Vernonia Amygdalina Del Fam. (asteraceae)

Leaf of Vernonia amygdalina has been shown to have hypoglycemic activity. This may be as a result of the presence of secondary metabolites as its constituents. The major secondary metabolites present in the leaf are tannins, carbohydrates, reducing sugars, glycosides, steroids and proteins. This work was designed to identify these... Continue Reading

51) Serum Profiles Of Pro-inflammatory Cytokines And Some Other Biomarkers Of Inflammation In Nigerian Tuberculosis Patients Undergoing Standard Chemotherapy At Enugu.

Introduction:Tuberculosis (TB) is a communicable disease that has afflicted man for centuries. It is one of the commonest causes of death from infectious diseases in the world. Nigeria is ranked among the 22 countries with the highest TB burden in the world. The discovery of host or pathogen specific biomarkers of TB for diagnosis, treatment, and... Continue Reading
  • Type:Project
  • ID:PHS0038
  • Pages:193

52) Evaluation Of The Subacute And Delayed Toxicity Of Artemether-lumefantrine Combination In Rats

  Despite the reported rapid increase in demand for artemisinin and its derivatives, there is little independent collaboration of the toxicity patterns of artemether-lumefantrine combination besides those documented by the manufacturer in its application for approval. It is however, pertinent to conduct an independent evaluation of the... Continue Reading
  • Type:Project
  • ID:PHS0037
  • Pages:136

53) Protective Role Of Aqueous Leaf Extract Of Vernonia Amygdalina Del. (asteraceae) And Ocimum Gratissimum Linn (lamiaceae) In Cyclophosphamide Induced Urotoxicity And Myelosuppression

  Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced... Continue Reading
  • Type:Project
  • ID:PHS0036
  • Pages:112

54) Assessment Of Antimicrobial And Phytochemical Properties Of Crude Leaf And Bark Extracts Of Ceiba Pentandra On Selected Clinical Isolates Found In Nigerian Teaching Hospital

Ceiba pentandra is a tropical tree of order Malvales and the family Malvaceae. The basic objective of this research work is to determine the antimicrobial and phytochemical properties of Ceiba pentandra. Fresh leaves and bark of Ceiba petandra was collected at Akungba Akoko. Ceiba pentandra (leaf and bark) were prepared for extraction... Continue Reading

55) Antibacterial Sensitivity Profile, Isolation And Identificati On Of Bacteria Using Api 20e Kits

The purpose of this research work is to determine the microbiological profile of hospital solid waste dump sites, sensitivity to antibiotic and isolation and identification of the organism using API 20 E kit method of analysis. Microbiological profiling was carried out on hospital solid waste collected from State Specialist Hospital in... Continue Reading

56) Antimicrobial Activity And Phytochemical Composition Of Crude Ethyl Acetate Extracts Of Anisopus Manni

 Anisopus mannii(Asclepiadaceae) –is a glabrous twining shrub, strong climber with greenish flower in globose, lateral umbelliform cymes it is widely used as an anti-diabetic agent in Northern and southern Nigerian traditional medicine, Studies were conducted to determine the phytochemical constituents of leaf and bark ethyl acetate extracts of... Continue Reading

57) Comparative Study Of The Antibacterial And Antifungal Spectrum, Phytochemi

 Piliostigma reticulatum plant found in West Africa. It is an Evergreen shrub with a twisted bole to 9 m high, with a bushy spherical canopy. Bark dark grey to brown, fibrous and corky, slash dark red. Leaves large, thick, leathery, grey-green, 6-12 cm long, Fruit large, long, straight, undulate or twisted and hard, either glabrous or sparsely... Continue Reading

58) Phytochemical And Proximate

The purpose of this present study of seven Nigerian medicinal plants is to ascertain the medicinal, phytochemical and proximate constituents of the plants. The plants are .Acacia albida Del,   Anchomanes difformis Engl,   Boscia senegalensis,   Bridelia ferruginea Benth,  Ficus ingens (Miq.) Miq,  Indigofera arrecta   Hochst   and ... Continue Reading

59) Antimicrobial, Phytochemical And Proximate Analysis Of Four Nigerian Medicinal Plants On Some Clinical Microorganisms

The increasing incidence of resistance to antibiotics among bacteria currently poses serious clinical and public health threat and has propelled efforts for newer alternatives to alleviate the problem. Extensive search and testing for different plants with potentials for antimicrobial properties is presently considered one of the most feasible... Continue Reading

60) Toxicity Assessment Of Stem Bark Extracts

Spondias mombin is depends on for various herbal remedies for the treatment of numerous health conditions. This study  is to evaluate the In-vivo toxic effect of Stem bark extracts of Spondias mombin on in male and female albino rats. In-vivo   toxicity test was carried out with modified Lorke’s method. Forty two (42) male and female albino... Continue Reading

61) Use Of Carica Papaya Seeds In A Suspension For The Treatment Of Intestinal Parasitic Worms

The seeds of a tropical fruit Carica papaya have been proven to have  anthelminthic activity. The main component in the seeds responsible for this  activity is Benzyl isothiocyanate. It is effective against parasites such Ascaris  lumbricoides, Strongyloides stercoralis, Taenia saginata and so on. The  research focus on formulating an... Continue Reading

62) Study On The Formulation Of Pantoprazole Microspheres And Tablets Using Mucuna Pruriens Starch

Microsphere drug delivery systems are used to protect sensitive drugs from enzymatic degradation in the body, for controlled release and tissue targeting of the drug of interest. Starch and products derived from starch modification, are increasingly gaining acceptance in microsphere drug delivery. They are less expensive, non-toxic,... Continue Reading
  • Type:Project
  • ID:PHS0027
  • Pages:149

63) Sustained Release Solid Lipid Nanoparticles Formulation Of Lumefantrine And Ciprofloxacin

    In the present study, optimized binary lipid matrices of Tallow fat- Transcutol and Precirol-Transcutol were used to formulate sustained release solid lipid nanoparticles loaded lumefantrine and ciprofloxacin. The homolipid (tallow fat from Bos indicus was extracted and purified following standard methods. Abinitio selection of lipid... Continue Reading
  • Type:Project
  • ID:PHS0026
  • Pages:216

64) Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets

Starch is a naturally occurring polymer found in parts of the plants such as leaves, stems, tubers, and fruits. It is a commonly used excipient in pharmaceutical formulations because of its availability, affordability and inertness. Cyperus esculentus (tiger nut) is widely cultivated in the country especially in the northern part of... Continue Reading
  • Type:Project
  • ID:PHS0025
  • Pages:156

65) Novel Drug Delivery Systems Containing Artesunate And Amodiaquine

  Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered... Continue Reading
  • Type:Project
  • ID:PHS0024
  • Pages:195

66) Studies On The In Vitro And In Vivo Interaction Of Cold Water Extract Of Azadirachta Indica (neem) Leaves With Some Antibiotics

T he present study investigated herb-drug interactions involving cold water extract of Azadirachta indica (neem) leaves, with five classes of antibiotics, namely: Tetracyclines - Tetracycline (TET) and Doxycycline POX); I Penicillins - Penicillin G(PG) and Ampicillin (AMP); Cephalosporins - Cefuroxime (CF); Arninoglycosides -Gentamicycin... Continue Reading
  • Type:Project
  • ID:PHS0023
  • Pages:118

67) Predicting Intestinal Permeation Of Drugs Through Neural Network Analysis Based On Five Molecular Descriptors

The oral route is generally preferred for drug administration because of its ease and good patient compliance. In the search for new drugs for oral administration a major problem encountered is obtaining drug structures which, as well as being potent in viiro, possess favourable pharmacokinetic profiles which enable them to pass easily... Continue Reading
  • Type:Project
  • ID:PHS0022
  • Pages:137

68) Antidiabetic Potentials Of Lipospheres Encapsulating Anogeissus Leiocarpus Dc Guill & Perr Root Bark Methanol Extract

The study was aimed at evaluating the antidiabetic potentials of Anogeissius leiocarpus DC Guill and Perr root bark methanol, ethanol and ethanol plus trona extract; and preparing, characterizing and evaluating lipospheres as drug delivery system loaded with A.leiocarpus root bark methanol extract. 400 mg/kg of methanol,ethanol and... Continue Reading
  • Type:Project
  • ID:PHS0021
  • Pages:114

69) Protective Role Of Aqueous Leaf Extract Of Vernonia Amygdalina Del. (asteraceae) And Ocimum Gratissimum Linn (lamiaceae) In Cyclophosphamide Induced Urotoxicity And Myelosuppression

Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced... Continue Reading
  • Type:Project
  • ID:PHS0020
  • Pages:112

70) Effect Of Ethanolic Leaf Extract Of Dialium Guineense Wild. (fabaceae) On Oral Glucose Tolerance In Mice And Alloxan-induced Diabetic Female Rats

This research project studied the effect of ethanolic leaf extract of Dialium guineense Willd (Fabaceae) on oral glucose tolerance in mice and alloxan-induced diabetic female rats.  The ethanolic leaf extract was prepared by marcerating 500g of the dried, milled leaves of D. guineense in 3L of 96% ethanol in a suitable sized plastic bucket/bowl... Continue Reading
  • Type:Project
  • ID:PHS0019
  • Pages:105

71) Anti-ulcerogenic Effects Of Chloroform Extract Of Chasmanthera Dependens On Indomethacin And Aspirin-iduced Ulcer In Rats

Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortal￾ity rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each... Continue Reading

72) Effect Of Combined Treatment With Chloroquine And Artesunate On White Blood Cell Count Of Plasomdium Berghei Infected Albino Mice

Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and... Continue Reading

73) Neutralization Of The Lethal Effect Of Bitis Arietans Venomby Euphorbia Cotinifolia Leaf Extract

TABLE OF CONTENTS CONTENTS PAGE TITLE PAGE - - - - - - - - - i DECLARATION - - - - - - - - ii CERTIFICATION - - - - - - - - iii DEDICATION - - - - - - - - iv ACKNOWLEDGEMENT - - - - - - - v TABLE OF CONTENT - - - - - - - vi LIST OF TABLES - - - - - - - - ix LIST OF FIGURES - - - - - - - ix ABSTRACT - - - - - - - - - x CHAPTER ONE INTRODUCTION AND... Continue Reading

74) Toxicity Assessment Of Stem Bark Extracts

Spondias mombin is depends on for various herbal remedies for the treatment of numerous health conditions. This study  is to evaluate the In-vivo toxic effect of Stem bark extracts of Spondias mombin on in male and female albino rats. In-vivo   toxicity test was carried out with modified Lorke’s method. Forty two (42) male and female albino... Continue Reading

75) Effect Of Aqeuous Extract Of Rauwola Vomitoria Root Extract On Isolated Rabbit Intestine

Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with... Continue Reading

76) Assessment Of Antimicrobial And Phytochemical Properties Of Crude Leaf And Bark Extracts Of Ceiba Pentandra On Selected Clinical Isolates Found In Nigerian Teaching Hospital

Ceiba pentandra is a tropical tree of order Malvales and the family Malvaceae. The basic objective of this research work is to determine the antimicrobial and phytochemical properties of Ceiba pentandra. Fresh leaves and bark of Ceiba petandra was collected at Akungba Akoko. Ceiba pentandra (leaf and bark) were prepared for extraction... Continue Reading

77) Use Of Carica Papaya Seeds In A Suspension For The Treatment Of Intestinal Parasitic Worms

The seeds of a tropical fruit Carica papaya have been proven to have anthelminthic activity. The main component in the seeds responsible for this activity is Benzyl isothiocyanate. It is effective against parasites such Ascaris lumbricoides, Strongyloides stercoralis, Taenia saginata and so on. The research focus on formulating an... Continue Reading

78) Antibacterial Sensitivity Profile, Isolation And Identificati On Of Bacteria Using Api 20e Kits

The purpose of this research work is to determine the microbiological profile of hospital solid waste dump sites, sensitivity to antibiotic and isolation and identification of the organism using API 20 E kit method of analysis. Microbiological profiling was carried out on hospital solid waste collected from State Specialist Hospital in... Continue Reading

79) Antimicrobial Activity And Phytochemical Composition Of Crude Ethyl Acetate Extracts Of Anisopus Manni

 Anisopus mannii(Asclepiadaceae) –is a glabrous twining shrub, strong climber with greenish flower in globose, lateral umbelliform cymes it is widely used as an anti-diabetic agent in Northern and southern Nigerian traditional medicine, Studies were conducted to determine the phytochemical constituents of leaf and bark ethyl acetate extracts of... Continue Reading

80) Comparative Study Of The Antibacterial And Antifungal Spectrum, Phytochemi

 Piliostigma reticulatum plant found in West Africa. It is an Evergreen shrub with a twisted bole to 9 m high, with a bushy spherical canopy. Bark dark grey to brown, fibrous and corky, slash dark red. Leaves large, thick, leathery, grey-green, 6-12 cm long, Fruit large, long, straight, undulate or twisted and hard, either glabrous or sparsely... Continue Reading

81) Phytochemical And Proximate

The purpose of this present study of seven Nigerian medicinal plants is to ascertain the medicinal, phytochemical and proximate constituents of the plants. The plants are .Acacia albida Del,   Anchomanes difformis Engl,   Boscia senegalensis,   Bridelia ferruginea Benth,  Ficus ingens (Miq.) Miq,  Indigofera arrecta   Hochst   and ... Continue Reading

82) Antimicrobial, Phytochemical And Proximate Analysis Of Four Nigerian Medicinal Plants On Some Clinical Microorganisms

The increasing incidence of resistance to antibiotics among bacteria currently poses serious clinical and public health threat and has propelled efforts for newer alternatives to alleviate the problem. Extensive search and testing for different plants with potentials for antimicrobial properties is presently considered one of the most feasible... Continue Reading

83) The Anxiolytic Activity Of Ethanolic Leaf Extract Of Culcasian Scadens In Experimental Animal Models

Objectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models . Methods:  The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided... Continue Reading

84) The Use Of Quality Control Parameters In The Evaluation Of Vegetable Crude Drugs

CHAPTER ONE INTRODUCTION  BACKGROUND OF THE STUDY The universal role of plants in the treatment of disease is exemplified by their employment in all the major systems of medicine irrespective of the underlying philosophical premise. How and when such medicinal plants... Continue Reading

85) Development Of Lipid-based Micro Suspensions For Ophthalmic Delivery Of Gentaamicin

The bioavailability of drugs from conventional eye drops is generally low. Many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense... Continue Reading

86) The Causes And Effects Of Cholera Among Children

This research work was designed to examine and analyze the causes and effects of cholera during raining season in Benin City. Seven (7) research questions were formulated and questionnaires were administered to one hundred and fifty (150) respondents in order to gather data for the research. Results showed that poor environment sanitation... Continue Reading

87) Availability And Storage Of Vaccines In Community Pharmacies

CHAPTER ONE INTRODUCTION 1.0 Background of the Study Immunization is the process by which an individual’s immune system becomes fortified against an agent (known as the immunogen). When this system is exposed to molecules that are foreign to the body, called non-self, it will orchestrate an immune response, and it will also develop the ability... Continue Reading

88) Profile Of Antibiotic Use At The Health Centre

The indiscriminate use of antibiotics has become a global problem with implications for effective therapy of infections and dose resistance. The objective of this study is to determine the profile of antibiotic use at the health centre of Delta State University, Abraka. This study was a retrospective study of 592 patient prescriptions... Continue Reading

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