SYNTHESIS AND ANTI-INFLAMMATORY PROPERTIES OF AMINOMETHYL DERIVATIVES OF 2 NAPHTHOL

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  • Department: Pharmaceutical Science
  • Project ID: PHS0084
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  • Pages: 197 Pages
  • Format: Microsoft Word
  • Views: 46
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ABSTRACT

The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid diseases cannot be over-emphasized. As this disease is characterized by chronic inflammation, it is usual to test compounds for anti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic drugs, From the literature, non-steroidal anti-inflammatory agents have covered a wide range of chemical structures aryl acetic, aryl-propionic, arylbutyric and anthranilic ' acid derivatives, Other compounds including the benzothiazines are also known to be potent agents. This work involved the synthesis of some amino methyl derivatives of 2-naphthol and screening them as potential anti-inflammatory agents. These derivatives from the point of view of their electronic and stereochemical characteristics are considered to be similar to the known bis(2-hydroxynaphthy1)- methane derivatives, earlier L'G+UL led iu ilave pronounced anti-inflammatory activity, The physicochemical properties of these compounds were .also determined in an effort to correlate observed biological activity and chemical structure.

SYNTHESIS AND ANTI-INFLAMMATORY PROPERTIES OF AMINOMETHYL DERIVATIVES OF 2 NAPHTHOL
For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

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  • Type: Project
  • Department: Pharmaceutical Science
  • Project ID: PHS0084
  • Access Fee: ₦3,000 ($9)
  • Pages: 197 Pages
  • Format: Microsoft Word
  • Views: 46
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    Type Project
    Department Pharmaceutical Science
    Project ID PHS0084
    Fee ₦3,000 ($9)
    No of Pages 197 Pages
    Format Microsoft Word

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