This research work investigates Manpower Training and Development and Bank Performance in Nigeria (1996 – 2015). Manpower training and development is a critical activity that causes changes in an organization. It is an action that helps a firm to stay alive. However, many organizations ignore it. In spite of huge amount spent in teaching and developing the employees, so as to make them to be more productive, some organizations still perform poorly. This work aims at determining the rate at which the training and development of manpower influence the gross earnings, profit after tax and earnings per share of banks. Using simple regression method, manpower training and development was regressed against gross earnings, profit after tax and earnings per share of Sterling Bank, WEMA Bank, First Bank Plc and Access Bank respectively. Data for the study were obtained from annual reports and accounts of the selected banks for a period of 20 years. The data collected were also subjected to unit root test, test for cointegration and test for serial correlation. In addition, primary data were collected from Diamond Bank, UBA, and Eco Bank and analyzed using chisquare. The study found that there is significant and positive relationship between manpower training and development and gross earnings, manpower training and development and profit after tax and manpower training and development and earnings per share. Based on the findings, the work concludes that there is significant direct relationship between manpower training and development and Bank performance in Nigeria. The work recommends, among others, that training programmes of the banks should be on a continuous basis and not when a bank has a particular problem.