The purpose of the study was to investigate the management of work place - related stress: the case of the Division of Human Resource Management Unit of UEW, Winneba. A sample of forty-five (45) participants was chosen for the study through simple random technique and purposive sampling techniques. Among others, it was found that: staff of the Human Resource Division of the University of Education, Winneba experience stress as a result of doing so many things within a limited time. To some extent, they also indicated that role conflict causes stressful situations at the workplace. Regarding the symptoms of stress, the staff of the Human Resource Division of the University of Education, Winneba reckoned that workers under stress are far more likely to make mistakes than workers in low stress jobs. They also opined that workers are much more likely to have to take time off work for stress-related sickness. They also agreed that workers under stress experience frequent urination and have sweating palms. Again, they indicated that workers under stress experience excessive tiredness and workers under stress often lose concentration. Among others, it was recommended that workers in the Human Resource Division of the University of Education, Winneba should ensure that they engage in physical activities such as regular exercises to their bodies. Also, in order not to have too much to do in a limited time, senior staff should delegate some of their responsibilities to their junior staff and the Human Resource Division in collaboration with the Management of the University should recruit more staff to relieve the staff of their heavy schedules.