Pharmaceutical Science Project Topics and Materials (Page 3)

 Piliostigma reticulatum plant found in West Africa. It is an Evergreen shrub with a twisted bole to 9 m high, with a bushy spherical canopy. Bark dark grey to brown, fibrous and corky, slash dark red. Leaves large, thick, leathery, grey-green, 6-12 cm long, Fruit large, long, straight, undulate or twisted and hard, either glabrous or sparsely... Continue Reading

The purpose of this present study of seven Nigerian medicinal plants is to ascertain the medicinal, phytochemical and proximate constituents of the plants. The plants are .Acacia albida Del,   Anchomanes difformis Engl,   Boscia senegalensis,   Bridelia ferruginea Benth,  Ficus ingens (Miq.) Miq,  Indigofera arrecta   Hochst   and ... Continue Reading

The increasing incidence of resistance to antibiotics among bacteria currently poses serious clinical and public health threat and has propelled efforts for newer alternatives to alleviate the problem. Extensive search and testing for different plants with potentials for antimicrobial properties is presently considered one of the most feasible... Continue Reading

Spondias mombin is depends on for various herbal remedies for the treatment of numerous health conditions. This study  is to evaluate the In-vivo toxic effect of Stem bark extracts of Spondias mombin on in male and female albino rats. In-vivo   toxicity test was carried out with modified Lorke’s method. Forty two (42) male and female albino... Continue Reading

ABSTRACT The seeds of a tropical fruit Carica papaya have been proven to have  anthelminthic activity. The main component in the seeds responsible for this  activity is Benzyl isothiocyanate. It is effective against parasites such Ascaris  lumbricoides, Strongyloides stercoralis, Taenia saginata and so on. The  research focus on formulating an... Continue Reading

ABSTRACT Microsphere drug delivery systems are used to protect sensitive drugs from enzymatic degradation in the body, for controlled release and tissue targeting of the drug of interest. Starch and products derived from starch modification, are increasingly gaining acceptance in microsphere drug delivery. They are less expensive, non-toxic,... Continue Reading

Abstract    In the present study, optimized binary lipid matrices of Tallow fat- Transcutol and Precirol-Transcutol were used to formulate sustained release solid lipid nanoparticles loaded lumefantrine and ciprofloxacin. The homolipid (tallow fat from Bos indicus was extracted and purified following standard methods. Abinitio selection of lipid... Continue Reading

ABSTRACT Starch is a naturally occurring polymer found in parts of the plants such as leaves, stems, tubers, and fruits. It is a commonly used excipient in pharmaceutical formulations because of its availability, affordability and inertness. Cyperus esculentus (tiger nut) is widely cultivated in the country especially in the northern part of... Continue Reading

ABSTRACT  Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered... Continue Reading

ABSTRACT T he present study investigated herb-drug interactions involving cold water extract of Azadirachta indica (neem) leaves, with five classes of antibiotics, namely: Tetracyclines - Tetracycline (TET) and Doxycycline POX); I Penicillins - Penicillin G(PG) and Ampicillin (AMP); Cephalosporins - Cefuroxime (CF); Arninoglycosides -Gentamicycin... Continue Reading

ABSTRACT The oral route is generally preferred for drug administration because of its ease and good patient compliance. In the search for new drugs for oral administration a major problem encountered is obtaining drug structures which, as well as being potent in viiro, possess favourable pharmacokinetic profiles which enable them to pass easily... Continue Reading

ABSTRACT The study was aimed at evaluating the antidiabetic potentials of Anogeissius leiocarpus DC Guill and Perr root bark methanol, ethanol and ethanol plus trona extract; and preparing, characterizing and evaluating lipospheres as drug delivery system loaded with A.leiocarpus root bark methanol extract. 400 mg/kg of methanol,ethanol and... Continue Reading

ABSTRACT Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced... Continue Reading

PROPOSAL: ABSTRACT Background: Currently stroke represents a serious problem in public health as one of the leading causes of  mortality and morbidity worldwide [1-3] with developing countries accounting for 85% of global deaths from stroke  [1, 3-5]. A very good example explains how stroke seems to be increasing in Nigeria and the case fatality... Continue Reading

The use of herbal medicines, despite the advancement in production of orthodox ones, has been on the increase, both in underdeveloped, developed and developing countries like Nigeria in particular. The approval of these herbal remedies by regulatory bodies like the National Agency for Food and Drug Administration Control, (NAFDAC) in Nigeria has... Continue Reading

The field of nano science plays a crucial role in modern research and technology, offering unparalleled opportunities for innovation. Spondias mombin extract is used in this study as a bioreducing agent for the biosynthesis of silver nanoparticles (AgNPs). The properties of these nanoparticles are compared. As the color of the extract changed from... Continue Reading

ABSTRACT  Fatty seed extracts of Vitellaria paradoxa (Sapotaceae), an indigenous plant of West Africa is a popular remedy for arthritis and swellings. This study investigated the knowledge, prevalence and pattern of use of the fatty extract also known as shea butter in clinically diagnosed arthritic patients as well as its effects on acute... Continue Reading

ABSTRACT The usefulness of non-steroidal anti-inflammatory agents in the management of rheumatoid diseases cannot be over-emphasized. As this disease is characterized by chronic inflammation, it is usual to test compounds for anti-inflammatory activity in animals and then hope that the active ones should be clinically useful as anti-rheumatic... Continue Reading

ABSTRACT Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered... Continue Reading

ABSTRACT The bioavailability of drugs from conventional eye drops is generally low. Many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense... Continue Reading

ABSTRACT This research work was designed to examine and analyze the causes and effects of cholera during raining season in Benin City. Seven (7) research questions were formulated and questionnaires were administered to one hundred and fifty (150) respondents in order to gather data for the research. Results showed that poor environment sanitation... Continue Reading

Abstract The indiscriminate use of antibiotics has become a global problem with implications for effective therapy of infections and dose resistance. The objective of this study is to determine the profile of antibiotic use at the health centre of Delta State University, Abraka. This study was a retrospective study of 592 patient prescriptions... Continue Reading

This research project studied the effect of ethanolic leaf extract of Dialium guineense Willd (Fabaceae) on oral glucose tolerance in mice and alloxan-induced diabetic female rats.  The ethanolic leaf extract was prepared by marcerating 500g of the dried, milled leaves of D. guineense in 3L of 96% ethanol in a suitable sized plastic bucket/bowl... Continue Reading

ABSTRACT Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and... Continue Reading

Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortal￾ity rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each... Continue Reading