ANTI-ULCEROGENIC EFFECTS OF CHLOROFORM EXTRACT OF CHASMANTHERA DEPENDENS ON INDOMETHACIN AND ASPIRIN-IDUCED ULCER IN RATS

  • Type: Project
  • Department: Pharmaceutical Science
  • Project ID: PHS0018
  • Access Fee: ₦5,000 ($14)
  • Pages: 7 Pages
  • Format: Microsoft Word
  • Views: 706
  • Report This work

For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortal￾ity rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera

dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into

two broad groups of twenty five rats each for aspirin and indomethacin models respectively. For

each model, twenty five adult rats divided into five groups of four rats each were used for ulcer

study. They were acclimatized for one week to laboratory conditions and fed with rat chow and water

al libitum. Two non-steroidal anti-inflammatory drugs, indomethacin and aspirin were used for ulcer

induction. They produced ulcer through topical mucosal irritation and inhibition of prostaglandin syn￾thesis. For each model, groups 3, 4 and 5 received the extract at doses of 100 mg/kg, 200 mg/kg

and 400 mg/kg while groups 1 and 2 served as the normal and standard control groups receiving

3 mg/kg normal saline and 100 mg/kg of ranitidine respectively. After acclimatization, the rats were

starved for 18 hours, then, extract doses, normal saline and ranitidine were intraperitoneally adminis￾tered to the various groups. Thirty minutes later, the ulcer inducing agents 100 mg/kg (indomethacin

and aspirin) were administered orally. The rats were kept under protection for another 8 hours before

being sacrificed by chloroform anesthesia. Their stomachs were isolated, cut along the greater

curvature and displayed for ulcer rating on a PVC board. Ulcer lesion in the groups were scored

and counted. The results of ulcer index obtained showed that rats pre-treated with the extract had

significant (p < 0.05) decrease in ulceration when compared to rats of the normal control. From this

study, the chloroform extract of Chasmanthera dependens root showed ulcer inhibitory properties

which were better than that exhibited by the standard drug (ranitidine).

Keywords: Anti-Ulcerogenic, Indomethacin, Aspirin-Induced, Ulcer, Chloroform Extract.

ANTI-ULCEROGENIC EFFECTS OF CHLOROFORM EXTRACT OF CHASMANTHERA DEPENDENS ON INDOMETHACIN AND ASPIRIN-IDUCED ULCER IN RATS
For more Info, call us on
+234 8130 686 500
or
+234 8093 423 853

Share This
  • Type: Project
  • Department: Pharmaceutical Science
  • Project ID: PHS0018
  • Access Fee: ₦5,000 ($14)
  • Pages: 7 Pages
  • Format: Microsoft Word
  • Views: 706
Payment Instruction
Bank payment for Nigerians, Make a payment of ₦ 5,000 to

Bank GTBANK
gtbank
Account Name Obiaks Business Venture
Account Number 0211074565

Bitcoin: Make a payment of 0.0005 to

Bitcoin(Btc)

btc wallet
Copy to clipboard Copy text

500
Leave a comment...

    Details

    Type Project
    Department Pharmaceutical Science
    Project ID PHS0018
    Fee ₦5,000 ($14)
    No of Pages 7 Pages
    Format Microsoft Word

    Related Works

    Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortality rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each for... Continue Reading
    Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortal￾ity rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each... Continue Reading
    ABSTRACT  Ten plant samples were screened for topical anti-inflammatory activity. PDI.ra/n hi~w,u leaf (Family: Commelinaceae) gave the highest activity. A gradient solvent extraction of the leaf will conducted using petroleum ether (40' - 60'). cliloroforcn and methanol respectivel~. The different fractions were tested for anti-~nflarnrnalot-y... Continue Reading
    ABSTRACT Ibuprofen, a strong analgesic and an anti-inflammatory drug used over a long period caused side effects such as peptic ulcer and constipation. Honeydew melon has been shown to possess anti-secretory, antiulcer and angiogenic. Hence, this study investigated the anti-ulcer effect of aqueous extract of honeydew melon on ibuprofen induced... Continue Reading
    ABSTRACT Hepatotoxicity and oxidative stress are some of the molecular mechanism of Dichlorvos toxicity. This study aims at dertermining the antipoisoning and protective properties of Elaeis oleifera palm oil extract in orally dichlorvos poisoned albino rats. 35 rats were divided into seven groups each containig five rats served as subject for... Continue Reading
    Abstract This study evaluated the anti-diabetic and antioxidant potential of methanolic extract of Helianthus annuus L. leaves in alloxan-induced hyperglycemic rats. Fresh leaves of the plant were collected from their local habitat in the University of Nigeria, Nsukka environment. The extract was prepared by cold maceration using 80 % methanol at... Continue Reading
    Abstract The changes in some haematological parameters in alloxan-induced diabetic rats treated with Terminalia catappa leaves extract and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) was studied. 54 male albino wister rats were selected into nine (9) groups of six (6) rats each. Diabetes was induced intraperitoneally to the test groups with... Continue Reading
    TABLE OF CONTENT Title Page Title Page - - - - - - - - - - i Dedication - - - - - - - - - - ii Declaration - - - - - - - - - - iii Certification - - - - - - - - - - iv Acknowledgement - - - - - - - - - v Table of Content - - - - - - - - - vii List of Table - - - - - - - - - xi List of Figures - - - - - - - - - xii Abstract - - - - - - - - - - xiii... Continue Reading
    Anti-diabetic and Anti-oxidant potentials of Aqueous Extract of Eucalyptus Globulus in experimentally induced diabetic rats.... Continue Reading
    Anti-diabetic and Anti-oxidant potentials of Aqueous Extract of Eucalyptus Globulus in experimentally induced diabetic rats.... Continue Reading
    Call Us
    Get this work
    whatsappWhatsApp Us