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ANTILIPIDEMIC EFFECT OF WATER (H20) EXTRACT OF DESMODIUM VELUTINUM LEAVES ON ALBINO WISTAR RATS.

  • Type:Project
  • Pages:52
  • Format:Microsoft Word
(Bio-Chemistry Project Topics & Materials)
ABSTRACT
This study evaluated the antilipidemic activity of water extracts from leaves of Desmodium velutinum on albino wistar rats. The phytochemical analysis of the leaf extract showed the presence of tannins, saponins, alkaloids, soluble carbohydrates, flavonoids, reducing sugar, steroids, cyanide and terpenoids. The animals were treated with known drugs (atorvastatin 2ml). There were significantly reductions in HDL 13.00 1.41 mg/dl LDL 1.20 0.14 mg/dl and triglyceride 39.00  0.14 mg/dl, compared with water extract of Desmodium velutinum (0.5ml). when administered was found to significantly reduce lipid plasma which was LDL 1.90
0.00mg/dl, triglyceride 50.00  0.00mg/dl and increase HDL 25.00  0.00 mg/dl which is the good cholesterol. The water extract of Desmodium velutinum leaf can possibly normalize the plasma lipid when compared with the group given atorvastatin. The phytochemicals analysis showed that the association between these complexes and compounds and other constituent play an important role in the biological activity of the leaf. This study suggested that the water extract of D.velutinum leaf posses hypolipidemic as well as antilipidemic effect.

TABLE OF CONTENTS

Title Page -- -- -- -- -- -- -- -- -- -- i
Certification -- -- -- -- -- -- -- -- -- ii
Dedication -- -- -- -- -- -- -- -- -- -- iii
Acknowledgment -- -- -- -- -- -- -- -- -- iv
List of Tables and Figures -- -- -- -- -- -- -- -- v
Table of Contents -- -- -- -- -- -- -- -- -- vi
Abstract -- -- -- -- -- -- -- -- -- -- ix
CHAPTER ONE
1.0 Introduction -- -- -- -- -- -- -- -- -- 2
1.2 Background of the Study - -- -- -- -- -- -- 2
CHAPTER TWO
2.0 Literature Review -- -- -- -- -- -- -- -- 3
2.1 Desmodium velutinum -- -- -- -- -- -- -- 3
2.1.2 Biological and Medicinal -- -- -- -- -- -- -- 5
2.1.3 Uses of other species Desmodium velutinum -- -- -- -- 5
2.2 Plants for Antilipidemic -- -- -- -- -- -- -- 7
2.2.1 Advantage of Medicinal Plants for Antilipidemic/
Cardiovascular Diseases over Synthetic Drugs -- -- -- 10
2.3 Lipids and Lipoprotein -- -- -- -- -- -- -- 11
2.3.1 Classification of Lipoprotein -- -- -- -- -- -- 13
2.3.2 Function of lipoprotein -- -- -- -- -- -- -- 14
2.4 Lipoprotein Disorder -- -- -- -- -- -- -- -- 17
2.5 Antilipidemic Drug (Atorvastatin) -- -- -- -- -- 18
2.5.1 Other Antilipidemic Drugs -- -- -- -- -- -- 22
2.5.2 Other therapies -- -- -- -- -- -- -- -- 26
2.5.3 Health Side Effects of Atorvastatin -- -- -- -- -- 27
CHAPTER THREE
Materials and Methods -- -- -- -- -- -- -- -- 28
3.1 Materials -- -- -- -- -- -- -- -- -- -- 28
3.1.1 Chemicals and Reagents -- -- -- -- -- -- -- 29
3.2 Plant Material -Collection and Identification -- -- -- -- 30
3.3 Extraction -- -- -- -- -- -- -- -- -- 30
3.4 Phytochemical Analysis -- -- -- -- -- -- -- 31
3.5 Experimental Animal Model -- -- -- -- -- -- 35
3.6 Collection of Blood Samples -- -- -- -- -- -- 38
3.7 Lipid Profile Analysis -- -- -- -- -- -- -- 38
CHAPTER FOUR
RESULT
4.0 Statically Analysis -- -- -- -- -- -- -- -- 45
4.1 Phytochemical Results -- -- -- -- -- -- -- 45
CHAPTER FIVE
DISCUSSION AND CONCLUSION
5.1 Discussion -- -- -- -- -- -- -- -- -- 48
5.2 Conclusion -- -- -- -- -- -- -- -- -- 51
References -- -- -- -- -- -- -- -- -- -- 52

ANTILIPIDEMIC EFFECT OF WATER (H20) EXTRACT OF DESMODIUM VELUTINUM LEAVES ON ALBINO WISTAR RATS.

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Details

Type Project
Department Bio-Chemistry
Project ID BCH0134
Price ₦3,000 ($9)
No of Pages 52 Pages
Format Microsoft Word

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    Details

    Type Project
    Department Bio-Chemistry
    Project ID BCH0134
    Price ₦3,000 ($9)
    No of Pages 52 Pages
    Format Microsoft Word

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