This research sought to investigate the influence of senior high school teachers' motivation on their work performance. The study also explored the techniques used by head teachers to motivate teachers to improve their work performance. The target population for this study comprised all teachers in the four selected senior high schools in the study area that consisted of total population of 505. Out of 505 teachers, 149 of them were randomly selected to participate in the study. Even with this sample selected, 125 representing 83.9% participated in the study. The study was conducted with quantitative research approach executed through questionnaires. The study employed descriptive cross-sectional design. The reliability of the overall instrument was 0.80 Cronbach alpha. The data collected were subjected to statistical analyses using frequencies, percentages and mean. Findings indicated that the factor that highly influences motivation of senior high school teachers in the Tamale Metropolis was teachers’ relations with their colleagues. Again, the level of motivation of senior high school teachers in the Tamale Metropolis study was at low level. Based on these findings, it was recommended that head masters should cooperate with teachers to establish effective teacher - teacher relationship. Again, motivation of teachers should be considered as a major driving force by head masters to foster good teacher job performance.